Endocrine Abstracts

The connective tissue components, collagen types I, III and IV, which surround the ovarian follicles, undergo drastic changes during ovulation. Abnormal collagen synthesis and increased volume and density of ovarian stroma characterise the polycystic ovary syndrome (PCOS). Physiologically, collagen synthesis in ovarian follicles is partly regulated by lysyl oxidase (LOX), which catalyzes the collagen and elastin cross-linking and plays indispensable role in the organization of...

The present study aimed to investigate whether dietary advanced glycation end-products (AGEs) are detected in the ovarian tissue of normal female rats and whether they affect metabolic or hormonal profile.Normal rats were randomly assigned to regular diet, high (H-AGE) or low (L-AGE) content for 6 months. Age-matched rats fed with regular diet served as controls.H-AGE rats, demonstrated higher levels of fasting glucose (P&#6...